NUTRINERVE
NUTRINERVE STUDIES

NutriNerve™ Patented Formulation - Supporting Medical Research NutriNerve 2.2 Provide Nutrition announces the introduction of NutriNerve 2.2 by NeuroEffex. NutriNerve contains a proprietary and patent pending balance of Alpha Lipoic Acid, Benfotiamine and Gamma-Linolenic Acid. The following medical research papers provide additional supporting data for these NutriNerve key ingredients.

Alpha Lipoic Acid
 

• Effect of 4-Year Antioxidant Treatment with [alpha]-Lipoic Acid in Diabetic Polyneuropathy: The NATHAN 1 Trial ADA Scientific Session – Oral Presentation 2007
• Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006 Nov;29(11):2365-70. Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs. Ter Arkh. 2005;77(10):15-9.
• Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes. Biochemistry (Mosc). 2004 Sep;69(9):1001-5.
• Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism. Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):315-23.
• Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia. 1998 Apr;41(4):390-9.
• Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78.

• At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. J Nutr. 2007 Feb;137(2):368-72.
• Botanicals and dietary supplements in diabetic peripheral neuropathy. J Am Board Fam Pract. 2003 Jan-Feb;16(1):47-57.
• Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism. Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):315-23.
• Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health. Ann Nutr Metab. 2001;45(2):47-57. Diabetic somatic polyneuropathy. Pathogenesis, clinical manifestations and therapeutic concepts. Fortschr Neurol Psychiatr. 2000 Jun;68(6):278-88.
• Beneficial effects of gamma linolenic acid supplementation on nerve conduction velocity, Na+, K+ ATPase activity, and membrane fatty acid composition in sciatic nerve of diabetic rats. J Nutr Biochem. 1999 Jul;10(7):411-20.
• Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia. 1998 Apr;41(4):390-9.
• Importance of Dietary Y-Linolenic Acid in Human Health and Nutrition. The Journal of Nutrition Vol. 128 No. 9 September 1998, pp. 1411-1414
• Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukot Essent Fatty Acids. 1996 Sep;55(3):159-65.

• Diabetic neuropathy: new strategies for treatment. Diabetes Obes Metab. 2007 Jun 26.
• Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006 Jan 13;530(1-2):48-53.
• Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005 Feb;43(2):71-7.
• Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung. 1999 Mar;49(3):220-4.
• Diabetic polyneuropathy treatment by milgamma-100 preparation. Zh Nevrol Psikhiatr Im S S Korsakova. 1998;98(9):30-2.
A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.